Ammonia → HCID 67152095, compound

HRID 2043844Notes

Reaction equation

HRID 2043844 reaction equation
Cl.[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[Cl:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=1.N>>[ClH:13].[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@@H:5]3[NH:12][C:18](=[O:19])[C:17]3[CH:21]=[CH:22][C:14]([Cl:13])=[CH:15][CH:16]=3)[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 63184-Chlorobenzoic AcidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 67152095HCID 67152095, compound

Procedure

Prepared from (4s)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 4-chlorobenzoic acid (Aldrich) according to methods A and C; yield 49 mg, 0.17 mmol (63%): 1H NMR (300 MHz, methanol-d4) δ 1.96 (d, J=14 Hz, 2H), 2.20 (s, 1H), 2.32 (d, J=14 Hz, 2H), 2.46 (s, 2H), 3.57 (s, 2H), 3.67 (s, 4H), 4.39 (s, 1H), 7.49 (d, J=8 Hz, 2H), 7.83 (d, J=8 Hz, 2H); MS (DCI/NH3) m/z 291 (M+H)+; Anal. C16H19ClN2O.HCl: C, H, N.

Sources & evidence

ORD record
ord-16dd9ee004de4ee78b37e00483291f12
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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