{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acid → HCID 67050264, compound

HRID 2043976Notes

Reaction equation

HRID 2043976 reaction equation
C(OC(=O)CSC1S[C:10]([NH:12][C:13]([N:15]([CH2:25][CH:26]2[CH2:30][CH2:29][CH2:28]C2)[C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([F:24])[CH:17]=2)=[O:14])=NC=1)C.C1(CN(C2C=CC(S(C)(=O)=O)=CC=2)C(=O)NC2SC=C(CC(O)=O)N=2)CCCC1.C1(CNC2C=CC(OC)=C(F)C=2)CCCC1.C([O:79][C:80](=[O:89])[CH:81]([S:83][C:84]1[S:88][CH:87]=[N:86][CH:85]=1)N)C>>[CH:25]1([N:15]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([F:24])[CH:17]=2)[C:13](=[O:14])[N:12]([CH3:10])[C:87]2[S:88][C:84]([S:83][CH2:81][C:80]([OH:79])=[O:89])=[CH:85][N:86]=2)[CH2:26][CH2:30][CH2:29][CH2:28]1

Participants

5

Reactant 4

HCID 57668194{2-[3-Cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]thiazol-4-yl}-acetic acidHCID 61343915N-(Cyclopentylmethyl)-3-fluoro-4-methoxyanilineHCID 67050212HCID 67050212, compoundHCID 86629925{2-[3-Cyclopentylmethyl-3-(3-fluoro-4-methoxy-phenyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester

Product 1

HCID 67050264HCID 67050264, compound

Procedure

The title compound was prepared via {2-[3-cyclopentylmethyl-3-(3-fluoro-4-methoxy-phenyl)ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(4-methanesulfonyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using cyclopentylmethyl-(3-fluoro-4-methoxy-phenyl)-amine and (2-amino-thiazol-5-ylsulfanylacetic acid ethyl ester.

Sources & evidence

ORD record
ord-dfd478175ca1461cbb9a1e0293eeb872
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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