Cyclopentanecarbaldehyde → HCID 57668387, compound

HRID 2043983Notes

Reaction equation

HRID 2043983 reaction equation
[CH:1]1([CH2:6][N:7]([C:20]2[CH:25]=[CH:24][C:23](F)=[C:22](F)[CH:21]=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][CH:12]=[C:13](CC(O)=O)[N:14]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.NC1C=C([NH:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])C=CC=1.C1(C=O)CCCC1.C([O:50][C:51](=[O:60])[CH2:52][S:53]C1SC(N)=NC=1)C>>[CH:1]1([CH2:6][N:7]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([NH:35][C:36](=[O:40])[CH:37]([CH3:38])[CH3:39])[CH:21]=2)[C:8](=[O:19])[NH:9][C:10]2[S:11][C:12]([S:53][CH2:52][C:51]([OH:60])=[O:50])=[CH:13][N:14]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 4

HCID 70106CyclopentanecarbaldehydeHCID 960757N-(3-aminophenyl)-2-methylpropanamideHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 57668246{2-[3-Cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid

Product 1

HCID 57668387HCID 57668387, compound

Procedure

The title compound was prepared via {2-[3-cyclopentylmethyl-3-(3-isobuturylamino-phenyl)ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester in a similar manner as described for the synthesis of {2-[3-cyclopentylmethyl-3-(3,4-difluoro-phenyl)-ureido]-thiazol-4-yl}-acetic acid, using N-(3-Amino-phenyl)-isobutyramide, cyclopentanecarbaldehyde and (2-amino-thiazol-5-ylsulfanyl)acetic acid ethyl ester.

Sources & evidence

ORD record
ord-208dcff6aa2340d58f44bdf5985fde7e
Source dataset
uspto-grants-2013_11
Patent number
US08586614B2

Reaction notes

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