反应详情

Heat a solution of ethyl 4,4,4-trifluoro-2-methylbut-2-enoic acid (0.544 g, 2.99 mmol) in 5M sulfuric acid (5 mL) at 120° C. for 2.5 days. Saturate the solution with sodium chloride and extract with diethyl ether (1×40 mL). Dry the organic phase with magnesium sulfate and concentrate under reduced pressure to provide 0.288 g (62.6%) of the title compound.

1. concentrationSaturate the solution with sodium chloride
2. extractionextract with diethyl ether (1×40 mL)
3. dry with materialDry the organic phase with magnesium sulfate
4. concentrationconcentrate under reduced pressure