HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4,4,4-trifluoro-2-methylbut-2-enoic acid → 4,4,4-Trifluoro-2-methylbut-2-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4,4,4-trifluoro-2-methylbut-2-enoic acid | HCID 53430161 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 4,4,4-Trifluoro-2-methylbut-2-enoic acid | HCID 53406079 | 62.6% |
Reaction Steps
Heat a solution of ethyl 4,4,4-trifluoro-2-methylbut-2-enoic acid (0.544 g, 2.99 mmol) in 5M sulfuric acid (5 mL) at 120° C. for 2.5 days. Saturate the solution with sodium chloride and extract with diethyl ether (1×40 mL). Dry the organic phase with magnesium sulfate and concentrate under reduced pressure to provide 0.288 g (62.6%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745438B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-3ccbdfc005e14e1288f33b802a9d1578 |
| Source note | uspto-grants-2010_06 |