反应详情

Add 40% palladium on carbon (0.064 g) to a solution of (E)-3-dipropylcarbamoyl-2-methylacrylic acid (0.20 g, 0.94 mmol) in tetrahydrofuran (20 mL). Hydrogenate at 60 psi for 18 hours. Filter through a filtering agent and concentrate filtrate under reduced pressure. Subject residue to silica gel chromatography, eluting with dichloromethane containing 10-40% of 5% (2:1 methanol:acetic acid) in dichloromethane to provide the title compound (0.134 g, 66.4%).

1. filtrationFilter through a filtering agent
2. concentrationconcentrate filtrate under reduced pressure
3. washSubject residue to silica gel chromatography, eluting with dichloromethane containing 10-40% of 5% (2:1 methanol:acetic acid) in dichloromethane