Piperazine → Benzoic acid, 2-bromo-4-(1-piperazinyl)-, methyl ester

HRID 2044988Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Br:7][C:8]1[CH:17]=[C:16](F)[CH:15]=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11]>>[Br:7][C:8]1[CH:17]=[C:16]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[CH:15]=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11]

Participants

Reactant 2

HCID 4837Piperazine

HCID 7210837Methyl 2-bromo-4-fluorobenzoate

Product 1

HCID 67227310Benzoic acid, 2-bromo-4-(1-piperazinyl)-, methyl ester

Procedure

The title compound was prepared by substituting piperazine for EXAMPLE 1B and methyl 2-bromo-4-fluorobenzoate for EXAMPLE 1C in EXAMPLE 1D.

Sources & evidence

ORD record: ord-c9eeb45439934dafbf7751d419a205a6
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586754B2

Reaction notes

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