Trifluoroacetic acid → HCID 178511244, compound

HRID 2045092Notes

Reaction equation

HRID 2045092 reaction equation
[C:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][NH:10]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1)#[N:2].FC(F)(F)C(O)=O>ClCCl>[NH2:10][CH2:9][C@H:6]1[CH2:7][CH2:8][C@H:3]([C:1]#[N:2])[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453599HCID 178453599, compound

Product 1

HCID 178511244HCID 178511244, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl (trans-4-cyanocyclohexyl)methylcarbamate (500 mg) in dichloromethane (10 mL) was slowly added trifluoroacetic acid (2 mL) at 0° C. The reaction mixture was warmed to room temperature, stirred for 1 hour and concentrated to provide the title compound.

Workup

  1. customat 0° C
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-807b9dedf16845c89cfab36aa8ca81f6
Source dataset
uspto-grants-2013_11
Patent number
US08586754B2

Reaction notes

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