反应详情

A mixture of 4-trifluoromethyl-phenylamine (2.6 mL, 21 mmol) and 3-nitro-benzaldehyde (3.44 g, 23 mmol) in ethanol (100 mL) was prepared. The reaction mixture was heated to reflux for 3 h. Then the reaction mixture cooled to room temperature. The solvent was removed in vacuo and the residue was washed with ether to afford (3-nitro-benzylidene)-(4-trifluoromethyl-phenyl)-amine (5.88 g, 95%) as a light yellow oil: LC/MS m/e calcd for C14H9F3N2O2 (M+H)+: 295.24, observed: 295.1.

1. customwas prepared
2. temperatureThe reaction mixture was heated
3. temperatureto reflux for 3 h
4. customThe solvent was removed in vacuo
5. washthe residue was washed with ether