反应详情

温度

20 °C

2-Chloro-6-iodoquinazolin-4-ol (3.5 g, 11.42 mmol) was suspended in EtOH and treated with an ethanolic solution of NaOEt (21%, 12.8 ml, 34.3 mmol). The mixture was irradiated at 150° C. in a microwave for 2 h, then was cooled to 20° C. The precipitated product was collected by filtration, and washed with aqueous HCl (1 N) and water. After drying under vacuum, the title compound (3.04 g, 84%) was obtained as a yellow solid. LCMS (ES+) m/z 317 (M+H)+.

1. customThe mixture was irradiated at 150° C. in a microwave for 2 h
2. filtrationThe precipitated product was collected by filtration
3. washwashed with aqueous HCl (1 N) and water
4. customAfter drying under vacuum