HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-(3-Hydroxyprop-1-ynyl)-3-(4-methoxyphenyl)chromen-2-one → 7-(3-Hydroxypropyl)-3-(4-methoxyphenyl)chromen-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-(3-Hydroxyprop-1-ynyl)-3-(4-methoxyphenyl)chromen-2-one | HCID 58402414 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-(3-Hydroxypropyl)-3-(4-methoxyphenyl)chromen-2-one | HCID 58402410 | — |
Reaction Steps
7-(3-Hydroxyprop-1-ynyl)-3-(4-methoxyphenyl)chromen-2-one is hydrogenated to completion in THF on palladium/active carbon catalyst. The catalyst is filtered off, the solvent is removed in vacuo, and the crude product is recrystallised from toluene/heptane (1:1), giving 7-(3-hydroxypropyl)-3-(4-methoxyphenyl)chromen-2-one as colourless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592007B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d3676b23e5e54d36bb1b60650c066ebe |
| Source note | uspto-grants-2013_11 |