反应详情

To a solution of ethyl 3-cyano-3-phenylpropanoate 2 (9.27 g, 45.6 mmol) in ethanol (70 mL) was added concentrated hydrochloric acid (2.4 mL) followed by 10% palladium on carbon (1.0 g) and the reaction hydrogenated at 80 psi for 18 h. The mixture was filtered through celite and concentrated in vacuo. The residue was triturated in ether and filtered to give 2 (4.97 g in 2 crops, 45%) as a white solid.

1. customthe reaction hydrogenated at 80 psi for 18 h
2. filtrationThe mixture was filtered through celite and
3. concentrationconcentrated in vacuo
4. customThe residue was triturated in ether
5. filtrationfiltered
6. customto give 2 (4.97 g in 2 crops, 45%) as a white solid