Sodium Acetate → HCID 59606521, compound

HRID 2045810Notes

Reaction equation

HRID 2045810 reaction equation
Cl.Cl[C:3]1[N:8]=[N:7][C:6]([N:9]([CH3:11])[CH3:10])=[C:5]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:4]=1.C([O-])(=O)C.[Na+]>CO.[Pd]>[CH3:10][N:9]([CH3:11])[C:6]1[N:7]=[N:8][CH:3]=[CH:4][C:5]=1[N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1

Participants

5

Reactant 2

HCID 517045Sodium AcetateHCID 86648150HCID 86648150, compound

Product 1

HCID 59606521HCID 59606521, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

9.4 g (6-chloro-4-piperazin-1-yl-pyridazin-3-yl)-dimethylamine hydrochloride and 7.3 g sodium acetate are suspended in 150 ml of methanol and hydrogenated with 1 g Pd/C 10% at ambient temperature. The catalyst is suction filtered, the filtrate is evaporated to dryness and the product is extracted with chloroform and washed with sodium hydroxide solution.

Workup

  1. filtrationfiltered
  2. customthe filtrate is evaporated to dryness
  3. extractionthe product is extracted with chloroform
  4. washwashed with sodium hydroxide solution

Sources & evidence

ORD record
ord-e3aa7f144dfe42b3bd7532b0857bcaaf
Source dataset
uspto-grants-2013_11
Patent number
US08592400B2

Reaction notes

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