反应详情

Lithium aluminum hydride (3.1 mL of 1.0 M solution in THF, 3.1 mmol) was added to a solution of methyl 3-ethylbenzoate (500 mg, 3.05 mmol) in THF (12 mL) at 0° C. After 2 h at 0° C., the reaction was quenched by the addition of saturated aqueous Rochelle's salt (50 mL) and stirred vigorously overnight at room temperature. The reaction mixture was extracted with Et2O (3×100 mL). The combined organic phase was dried (Na2SO4), filtered and concentrated in vacuo to afford (3-ethylphenyl)methanol which was shown to be ˜90% pure by 1H NMR analysis and was taken on without further purification.

1. customthe reaction was quenched by the addition of saturated aqueous Rochelle's salt (50 mL)
2. extractionThe reaction mixture was extracted with Et2O (3×100 mL)
3. dry with materialThe combined organic phase was dried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo