Dichloromethane → Cyclopropyl-{4-[6-fluoro-2-phenoxymethyl-3-(4-trifluoromethoxy-benzyl)-3H-benzoimidazol-5-yl]-piperazin-1-yl}-methanone

HRID 204587Notes

Reaction equation

HRID 204587 reaction equation
[CH:37]1([C:40](=[O:41])[Cl:42])[CH2:38][CH2:39]1.[Cl:43][CH2:44][Cl:45].[F:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH2:17][c:18]3[cH:19][cH:20][c:21]([O:24][C:25]([F:26])([F:27])[F:28])[cH:22][cH:23]3)[c:7]([CH2:9][O:10][c:11]3[cH:12][cH:13][cH:14][cH:15][cH:16]3)[n:8]2)[cH:29][c:30]1[N:31]1[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]1>>[F:1][c:2]1[cH:3][c:4]2[c:5]([n:6]([CH2:17][c:18]3[cH:19][cH:20][c:21]([O:24][C:25]([F:26])([F:27])[F:28])[cH:22][cH:23]3)[c:7]([CH2:9][O:10][c:11]3[cH:12][cH:13][cH:14][cH:15][cH:16]3)[n:8]2)[cH:29][c:30]1[N:31]1[CH2:32][CH2:33][N:34]([C:40]([CH:37]2[CH2:38][CH2:39]2)=[O:41])[CH2:35][CH2:36]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 77637Cyclopropanecarbonyl chlorideHCID 684671025-fluoro-2-phenoxymethyl-6-piperazin-1-yl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole

Product 1

HCID 68466187Cyclopropyl-{4-[6-fluoro-2-phenoxymethyl-3-(4-trifluoromethoxy-benzyl)-3H-benzoimidazol-5-yl]-piperazin-1-yl}-methanone

Sources & evidence

ORD record
ord-8e0f152cc56c47af8043a6597468e2c1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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