化工社化工社 化学情報印刷レポート · 研究参考用
Water → 6-Chloro-2,4-dimethylpyridazin-3(2H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3(2H)-Pyridazinone, 6-chloro-4-methyl- | HCID 164886 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Chloro-2,4-dimethylpyridazin-3(2H)-one | HCID 59845973 | — |
反応手順
Methyl iodide (1.3 mL) was added to a mixture of 6-chloro-4-methyl-2H-pyridazin-3-one (2.70 g) and K2CO3 (3.40 g) in dimethylformamide (27 mL). The resulting mixture was stirred at ambient temperature overnight. Then, water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with water and brine and dried (MgSO4). After removal of the solvent, the title compound was obtained as a solid. Yield: 2.97 g (100% of theory). Mass spectrum (ESI+): m/z=159/161 (CI) [M+H]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08592410B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-5a33a3084e78496f85dadaae6d3a200f |
| 出典メモ | uspto-grants-2013_11 |