Water → 6-Chloro-2,4-dimethylpyridazin-3(2H)-one

HRID 2046011ノート

反応式

HRID 2046011 の反応式
CI.[Cl:3][C:4]1[CH:5]=[C:6]([CH3:11])[C:7](=[O:10])[NH:8][N:9]=1.[C:12]([O-])([O-])=O.[K+].[K+].O>CN(C)C=O>[Cl:3][C:4]1[CH:5]=[C:6]([CH3:11])[C:7](=[O:10])[N:8]([CH3:12])[N:9]=1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 1648863(2H)-Pyridazinone, 6-chloro-4-methyl-

生成物 1

HCID 598459736-Chloro-2,4-dimethylpyridazin-3(2H)-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Methyl iodide (1.3 mL) was added to a mixture of 6-chloro-4-methyl-2H-pyridazin-3-one (2.70 g) and K2CO3 (3.40 g) in dimethylformamide (27 mL). The resulting mixture was stirred at ambient temperature overnight. Then, water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with water and brine and dried (MgSO4). After removal of the solvent, the title compound was obtained as a solid. Yield: 2.97 g (100% of theory). Mass spectrum (ESI+): m/z=159/161 (CI) [M+H]+

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe combined organic extracts were washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customAfter removal of the solvent

出典と根拠

ORDレコード
ord-5a33a3084e78496f85dadaae6d3a200f
出典データセット
uspto-grants-2013_11
特許番号
US08592410B2

反応ノート

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