4-(tert-Butyldimethylsiloxy)phenol → 2-[4-(tert-Butyl-dimethyl-silanyloxy)-phenoxymethyl]-5-(5-fluoro-pyridin-2-yl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
Reaction equation
[O:1]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].[F:16][C:17]1[CH:18]=[CH:19][C:20]([N:23]2[CH2:28][CH2:27][N:26]3[N:29]=[C:30]([CH2:32]O)[CH:31]=[C:25]3[C:24]2=[O:34])=[N:21][CH:22]=1.FC1C=CC(N2CCN3N=C(COC4C=CC(C)=CC=4)C=C3C2=O)=CC=1>>[C:5]([Si:2]([CH3:4])([CH3:3])[O:1][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:32][C:30]2[CH:31]=[C:25]3[C:24](=[O:34])[N:23]([C:20]4[CH:19]=[CH:18][C:17]([F:16])=[CH:22][N:21]=4)[CH2:28][CH2:27][N:26]3[N:29]=2)=[CH:11][CH:10]=1)([CH3:8])([CH3:7])[CH3:6]Participants
4
Reactant 3
Product 1
Procedure
The compound was prepared from 4-(tert-butyldimethylsiloxy)phenol and 5-(5-fluoro-pyridin-2-yl)-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one using the method described in the preceding example 55 (5-(4-fluorophenyl)-2-(p-tolyloxymethyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).
Sources & evidence
- ORD record
- ord-4535b881d23645179d81b4788a0014f7
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08592422B2
Reaction notes
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