Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrazine-2-carboxylate → 3-Chloro-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester
Reaction equation
C(O[C:4]([C:6]1[C:10]([Cl:11])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][N:7]=1)=[O:5])C.C(O[C:20]([C:22]1[N:23](CCNC(OC(C)(C)C)=O)N=C(COC2C=CC=CC=2)C=1)=O)C.C(OC(C1C=C2C(=O)NCCN2N=1)=O)C>>[CH2:15]([O:14][C:12]([C:9]1[C:10]([Cl:11])=[C:6]2[C:4](=[O:5])[NH:23][CH2:22][CH2:20][N:7]2[N:8]=1)=[O:13])[CH3:16]Participants
4
Procedure
The compound was prepared from 4-chloro-1H-pyrazole-3,5-dicarboxylic acid diethyl ester and 2-(2-tert-butoxycarbonylamino)ethyl bromide using the methods described in the preceding examples 5 (2-(2-tert-butoxycarbonylamino-ethyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester) and 48 (4,5,6,7-tetrahydro-4-oxo-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester.
Sources & evidence
- ORD record
- ord-21cb41255c554df89ddab2730b41478d
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08592422B2
Reaction notes
Loading…