3,5-diethyl 4-iodo-1H-pyrazole-3,5-dicarboxylate → 1-(2-tert-Butoxycarbonylamino-ethyl)-4-iodo-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

HRID 2046234Notes

Reaction equation

HRID 2046234 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]([I:11])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][N:7]=1)=[O:5])[CH3:2].C(OC(C1N([CH2:35][CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])N=C(COC2C=CC=CC=2)C=1)=O)C>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([I:11])=[C:9]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:8]([CH2:35][CH2:36][NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[N:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 117392303,5-diethyl 4-iodo-1H-pyrazole-3,5-dicarboxylateHCID 679582242-(2-tert-Butoxycarbonylamino-ethyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester

Product 1

HCID 679758161-(2-tert-Butoxycarbonylamino-ethyl)-4-iodo-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

Procedure

The compound was prepared from 4-iodo-1H-pyrazole-3,5-dicarboxylic acid diethyl ester and 2-(2-tert-butoxycarbonylamino)ethyl bromide using the method described in the preceding example 5 (2-(2-tert-butoxycarbonylamino-ethyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester).

Sources & evidence

ORD record
ord-f42d332cd7b6453a8beec81efeb796c8
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

Loading…