Dimethylamine → (6-Chloro-5-methyl-pyridin-2-yl)-dimethyl-amine

HRID 2046239노트

반응식

HRID 2046239 반응식
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[N:3]=1.[CH3:10][NH:11][CH3:12]>C(Cl)Cl>[Cl:1][C:2]1[N:3]=[C:4]([N:11]([CH3:12])[CH3:10])[CH:5]=[CH:6][C:7]=1[CH3:8].[Cl:9][C:4]1[N:3]=[C:2]([N:11]([CH3:12])[CH3:10])[C:7]([CH3:8])=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 674DimethylamineHCID 8170882,6-Dichloro-3-methylpyridine

생성물 2

HCID 86670205(6-Chloro-5-methyl-pyridin-2-yl)-dimethyl-amineHCID 86670206(6-Chloro-3-methyl-pyridin-2-yl)-dimethyl-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
80 °C

실험 절차

2,6-Dichloro-3-methylpyridine (250 mg, 1.5 mmol) was dissolved in a 40% aqueous solution of dimethylamine (0.2 mL, 1.5 mmol) and stirred at 80° C. in a sealed tube for 16 hours. Then DCM was added. The organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo to yield (6-chloro-5-methyl-pyridin-2-yl)-dimethyl-amine and (6-chloro-3-methyl-pyridin-2-yl)-dimethyl-amine as a colorless oil that was used in the next step without further purification.

후처리

  1. customThe organic layer was separated
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-25c29cb1f33c42caa373145897a8b8bd
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592422B2

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