HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2046239Generated: October 25, 2026
Dimethylamine → (6-Chloro-5-methyl-pyridin-2-yl)-dimethyl-amine
https://huagongshe.com/reaction/2046239
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 2,6-Dichloro-3-methylpyridine | HCID 817088 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (6-Chloro-5-methyl-pyridin-2-yl)-dimethyl-amine | HCID 86670205 | — |
| Product | (6-Chloro-3-methyl-pyridin-2-yl)-dimethyl-amine | HCID 86670206 | — |
Reaction Steps
2,6-Dichloro-3-methylpyridine (250 mg, 1.5 mmol) was dissolved in a 40% aqueous solution of dimethylamine (0.2 mL, 1.5 mmol) and stirred at 80° C. in a sealed tube for 16 hours. Then DCM was added. The organic layer was separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo to yield (6-chloro-5-methyl-pyridin-2-yl)-dimethyl-amine and (6-chloro-3-methyl-pyridin-2-yl)-dimethyl-amine as a colorless oil that was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08592422B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-25c29cb1f33c42caa373145897a8b8bd |
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| Source note | uspto-grants-2013_11 |
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