1-Cyclopropanecarbonyl-N-methylpiperidin-4-amine → 2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamide

HRID 2046379Notes

Reaction equation

HRID 2046379 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][CH2:9][C:10]([O:12]CC)=O)=[CH:4][CH:3]=1.[CH:15]1([C:18]([N:20]2[CH2:25][CH2:24][CH:23]([NH:26][CH3:27])[CH2:22][CH2:21]2)=[O:19])[CH2:17][CH2:16]1>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([O:8][CH2:9][C:10]([N:26]([CH:23]2[CH2:24][CH2:25][N:20]([C:18]([CH:15]3[CH2:17][CH2:16]3)=[O:19])[CH2:21][CH2:22]2)[CH3:27])=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 608178661-Cyclopropanecarbonyl-N-methylpiperidin-4-amineHCID 86641965Ethyl 2-(6-chloropyridazine-3-yloxy)acetate

Product 1

HCID 866419642-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamideYield 63%

Procedure

The title compound was synthesized from ethyl 2-(6-chloropyridazine-3-yloxy)acetate and cyclopropyl (4-(methylamino)piperidine-1-yl)methanone in the same manner as in Example 105 (63% yield, in 2 steps).

Sources & evidence

ORD record
ord-5fdfa4b176ce4bd88f8d8ca3c199216b
Source dataset
uspto-grants-2013_11
Patent number
US08592435B2

Reaction notes

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