HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclopropanecarbonyl-N-methylpiperidin-4-amine → 2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclopropanecarbonyl-N-methylpiperidin-4-amine | HCID 60817866 | — |
| Reactant | Ethyl 2-(6-chloropyridazine-3-yloxy)acetate | HCID 86641965 | — |
| Product | 2-(6-chloropyridazine-3-yloxy)-N-(1-(cyclopropanecarbonyl)piperidine-4-yl)-N-methylacetamide | HCID 86641964 | 63% |
Reaction Steps
The title compound was synthesized from ethyl 2-(6-chloropyridazine-3-yloxy)acetate and cyclopropyl (4-(methylamino)piperidine-1-yl)methanone in the same manner as in Example 105 (63% yield, in 2 steps).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592435B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-5fdfa4b176ce4bd88f8d8ca3c199216b |
| Source note | uspto-grants-2013_11 |