Dichloromethane → Dimethyl 2-(3-tert-butylphenyl)piperidine-1,4-dicarboxylate

HRID 204642Notes

Reaction equation

HRID 204642 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([CH:11]2[NH:12][CH2:13][CH2:14][CH:15]([C:17](=[O:18])[O:19][CH3:20])[CH2:16]2)[cH:8][cH:9][cH:10]1.[C:30]([O:31][CH3:32])(=[O:33])[Cl:34].[CH:21]([N:22]([CH2:23][CH3:24])[CH:25]([CH3:26])[CH3:27])([CH3:28])[CH3:29].[Cl:35][CH2:36][Cl:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([CH:11]2[N:12]([C:30]([O:31][CH3:32])=[O:33])[CH2:13][CH2:14][CH:15]([C:17](=[O:18])[O:19][CH3:20])[CH2:16]2)[cH:8][cH:9][cH:10]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6586Methyl chloroformateHCID 81531DiisopropylethylamineHCID 66731564Methyl 2-(3-tert-butylphenyl)piperidine-4-carboxylate

Product 1

HCID 66734775Dimethyl 2-(3-tert-butylphenyl)piperidine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-cf935836db724bf989678f4c57675d17
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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