Dimethylformamide dimethyl acetal → 5-(4-Chlorophenyl)-2-[(dimethylamino)methylene]-1,3-cyclohexanedione

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Reaction Steps

5-(4-Chloro-phenyl)-cyclohexane-1,3-dione (1.0 g, 4.5 mmol) was suspended in N,N-dimethylformamide dimethylacetal (5 ml) and heated at reflux for 4 h. The reaction mixture was cooled to ambient temperature and the precipitate was filtered, washed with diethyl ether and dried under air suction. The required product was obtained as a yellow solid which was used in the next step without further purification.

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