HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → 2-amino-7-(4-fluorophenyl)-7,8-dihydroquinazolin-5(6H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 2772371 | — |
| Reactant | 2-[(Dimethylamino)methylene]-5-(4-fluorophenyl)-1,3-cyclohexanedione | HCID 28742129 | — |
| Product | 2-amino-7-(4-fluorophenyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 4583122 | — |
Reaction Steps
The title compound was prepared from 2-dimethylaminomethylene-5-(4-fluoro-phenyl)-cyclohexane-1,3-dione (600 mg, 2.29 mmol) prepared in stage 1, guanidine hydrochloride (438 mg, 4.59 mmol) and sodium carbonate (728 mg, 6.87 mmol), following the procedure described for 2-amino-7-(4-chloro-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/a stage 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592430B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-85ece1ca3c8b40778bdb669872249567 |
| Source note | uspto-grants-2013_11 |