Morpholine → HCID 76750934, compound

HRID 2046456Notes

Reaction equation

HRID 2046456 reaction equation
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[N:12][O:13][CH2:14][C:15]([OH:17])=O)[CH2:7][CH:6]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH2:5][C:4]=2[N:3]=1.S(Cl)(Cl)=O.[NH:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1.C(N(CC)CC)C>C(Cl)Cl>[N:29]1([C:15](=[O:17])[CH2:14][O:13][N:12]=[C:8]2[CH2:7][CH:6]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[CH2:5][C:4]3[N:3]=[C:2]([NH2:1])[N:11]=[CH:10][C:9]2=3)[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1

Participants

6

Reactant 4

HCID 8083MorpholineHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 76750915HCID 76750915, compound

Product 1

HCID 76750934HCID 76750934, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from [2-amino-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-ylideneaminooxy]-acetic acid, compound 9, and thionyl chloride forming the acid chloride followed by amidation using morpholine and triethylamine in DCM.

Sources & evidence

ORD record
ord-b831ef25bd77489997ff6deb76ca18bd
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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