2-Acetyl-5-(furan-2-yl)cyclohexane-1,3-dione → 2-amino-7-(furan-2-yl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one

HRID 2046469Notes

Reaction equation

HRID 2046469 reaction equation
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[O:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]1=O)(=O)[CH3:2].[NH2:17][C:18]1[N:27]=C(C)C2C(=O)CC(C3C=CC(F)=CC=3)CC=2[N:19]=1>>[NH2:27][C:18]1[N:19]=[C:1]([CH3:2])[C:4]2[C:9](=[O:10])[CH2:8][CH:7]([C:11]3[O:12][CH:13]=[CH:14][CH:15]=3)[CH2:6][C:5]=2[N:17]=1

Participants

3

Reactant 2

HCID 53059482-Acetyl-5-(furan-2-yl)cyclohexane-1,3-dioneHCID 172212082-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one

Product 1

HCID 29884362-amino-7-(furan-2-yl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one

Procedure

The title compound was prepared from 2-acetyl-5-furan-2-yl-cyclohexane-1,3-dione (321 mg, 1.46 mmol), from stage 1, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/a stage 2/3).

Sources & evidence

ORD record
ord-7118d695b3a44275b323fc9a20893a2f
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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