2-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one → 2-Amino-7-thien-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one

HRID 2046472Notes

Reaction equation

HRID 2046472 reaction equation
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]1=O)(=O)[CH3:2].[NH2:17][C:18]1[N:27]=C(C)C2C(=O)CC(C3C=CC(F)=CC=3)CC=2[N:19]=1>>[NH2:27][C:18]1[N:19]=[C:1]([CH3:2])[C:4]2[C:9](=[O:10])[CH2:8][CH:7]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH2:6][C:5]=2[N:17]=1

Participants

3

Reactant 2

HCID 172212082-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-oneHCID 529502492-Acetyl-5-thien-2-yl-cyclohexane-1,3-dione

Product 1

HCID 172212112-Amino-7-thien-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one

Procedure

The title compound was prepared from 2-acetyl-5-thien-2-yl-cyclohexane-1,3-dione (430 mg, 1.82 mmol), from stage 1, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one.

Sources & evidence

ORD record
ord-cd1f57a462ed4f5ab3ccc7175d9d4059
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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