Sodium Acetate → 2-Acetyl-5-p-tolyl-cyclohexane-1,3-dione

HRID 2046473Notes

Reaction equation

[C:1]1([CH3:15])[CH:6]=[CH:5][C:4]([CH:7]2[CH2:12][C:11](=[O:13])[CH2:10][C:9](=[O:14])[CH2:8]2)=[CH:3][CH:2]=1.[C:16]([O-])(=[O:18])[CH3:17].[Na+].C(C1C(=O)CC(C2C=CC(F)=CC=2)CC1=O)(=O)C>>[C:16]([CH:10]1[C:9](=[O:14])[CH2:8][CH:7]([C:4]2[CH:3]=[CH:2][C:1]([CH3:15])=[CH:6][CH:5]=2)[CH2:12][C:11]1=[O:13])(=[O:18])[CH3:17]

Participants

Reactant 3

HCID 517045Sodium Acetate

HCID 5764925-(4-Methylphenyl)cyclohexane-1,3-dione

HCID 529508832-Acetyl-5-(4-fluoro-phenyl)cyclohexane-1,3-dione

Product 1

HCID 582694112-Acetyl-5-p-tolyl-cyclohexane-1,3-dione

Procedure

The title compound was prepared from 5-p-tolyl-cyclohexane-1,3-dione (1.6 g, 5.74 mmol), from example 1/c stage 2, and sodium acetate (470 mg, 5.74 mmol), following the procedure describing the synthesis of 2-acetyl-5-(4-fluoro-phenyl)-cyclohexane-1,3-dione (example 3/a stage 1).

Sources & evidence

ORD record: ord-6a9b5b31d77b4c3ea27469049e93bf4e
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592430B2

Reaction notes

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