Sodium Acetate → 2-Acetyl-5-(2-methoxyphenyl)cyclohexane-1,3-dione

HRID 2046475Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][C:13](=[O:15])[CH2:12][C:11](=[O:16])[CH2:10]1.[C:17]([O-])(=[O:19])[CH3:18].[Na+].C(C1C(=O)CC(C2C=CC(F)=CC=2)CC1=O)(=O)C>>[C:17]([CH:12]1[C:11](=[O:16])[CH2:10][CH:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[CH2:14][C:13]1=[O:15])(=[O:19])[CH3:18]

Participants

Reactant 3

HCID 517045Sodium Acetate

HCID 171223135-(2-Methoxyphenyl)-1,3-cyclohexanedione

HCID 529508832-Acetyl-5-(4-fluoro-phenyl)cyclohexane-1,3-dione

Product 1

HCID 183173522-Acetyl-5-(2-methoxyphenyl)cyclohexane-1,3-dione

Procedure

The title compound was prepared from 5-(2-methoxy-phenyl)-cyclohexane-1,3-dione (1.0 g, 4.58 mmol), example 1/a, and sodium acetate (376 mg, 4.58 mmol), following the procedure describing the synthesis of 2-acetyl-5-(4-fluoro-phenyl)-cyclohexane-1,3-dione (example 3/a stage 1).

Sources & evidence

ORD record: ord-2bf71919d38b483d98f2647d008e4ff5
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592430B2

Reaction notes

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