Phenylboronic Acid → HCID 58269337, compound

HRID 2046483Notes

Reaction equation

HRID 2046483 reaction equation
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][CH:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3Br)[CH2:5][C:4]=2[N:3]=1.NC1N=C[C:28]2[C:27](=O)[CH2:26][CH:25](C3C=CC(F)=CC=3C3C=NC=CC=3)[CH2:24][C:23]=2N=1.C1(B(O)O)C=CC=CC=1>>[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][CH:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:5][C:4]=2[N:3]=1

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 58269374HCID 58269374, compoundHCID 58269407HCID 58269407, compound

Product 1

HCID 58269337HCID 58269337, compound

Procedure

The title compound was prepared from 2-amino-7-(2-bromo-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/h stage 2), following the procedure describing the synthesis of 2-amino-7-(4-fluoro-2-pyridin-3-yl-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 4/a stage 1) except for phenylboronic acid replacing 3-pyridylboronic acid.

Sources & evidence

ORD record
ord-16d98b3d78714c3ea4a35e43e6dd4778
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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