Morpholine → HCID 76750936, compound

HRID 2046484Notes

Reaction equation

HRID 2046484 reaction equation
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[N:12][O:13][CH2:14][C:15]([OH:17])=O)[CH2:7][CH:6]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:5][C:4]=2[N:3]=1.S(Cl)(Cl)=O.[NH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1.C(N(CC)CC)C>C(Cl)Cl>[N:34]1([C:15](=[O:17])[CH2:14][O:13][N:12]=[C:8]2[CH2:7][CH:6]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:5][C:4]3[N:3]=[C:2]([NH2:1])[N:11]=[CH:10][C:9]2=3)[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1

Participants

6

Reactant 4

HCID 8083MorpholineHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 76750932HCID 76750932, compound2×

Product 1

HCID 76750936HCID 76750936, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-amino-7-biphenyl-2-yl-7,8-dihydro-6H-quinazolin-5-ylideneaminooxy)-acetic acid (compound 54) by treating with thionyl chloride followed by amidation using morpholine and triethylamine in DCM.

Sources & evidence

ORD record
ord-a9229ce84e3346e3a363e0ce4cb04630
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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