HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 76750940, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 21914305 | HCID 21914305 | — |
| Reactant | 2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime | HCID 76750894 | — |
| Reactant | 2-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(3-dimethylamino-propyl)-oxime | HCID 86653555 | — |
| Product | HCID 76750940 | HCID 76750940 | — |
Reaction Steps
The title compound was prepared from 2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime, compound 66, (30 mg, 0.087 mmol), 2-(chloro-ethyl)-morpholine hydrochloride (32 mg, 0.214 mmol) and sodium hydride (60% dispersion in oil) (18 mg, 0.470 mmol), following the same procedure used for 2-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(3-dimethylamino-propyl)-oxime (compound 88).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592430B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-45688e9a3a06495bb9533b24aa58a7fb |
| Source note | uspto-grants-2013_11 |