Sodium hydride → HCID 76750940, compound

HRID 2046497Notes

Reaction equation

HRID 2046497 reaction equation
NC1N=C(C)C2C(=NO)CC(C3C=CC=CC=3C3C=CC=CC=3)CC=2N=1.Cl.ClCC[CH:31]1[O:36][CH2:35][CH2:34][NH:33][CH2:32]1.[H-].[Na+].CN(C)C[CH2:42][CH2:43][O:44][N:45]=[C:46]1[CH2:55][CH:54]([C:56]2[CH:61]=[C:60](F)[CH:59]=[CH:58][C:57]=2[C:63]2[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=2)[CH2:53][C:52]2[N:51]=[C:50]([NH2:69])[N:49]=[C:48]([CH3:70])[C:47]1=2>>[N:33]1([CH2:42][CH2:43][O:44][N:45]=[C:46]2[CH2:55][CH:54]([C:56]3[CH:61]=[CH:60][CH:59]=[CH:58][C:57]=3[C:63]3[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=3)[CH2:53][C:52]3[N:51]=[C:50]([NH2:69])[N:49]=[C:48]([CH3:70])[C:47]2=3)[CH2:32][CH2:31][O:36][CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 24758Sodium hydrideHCID 21914305HCID 21914305, compoundHCID 767508942-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oximeHCID 866535552-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(3-dimethylamino-propyl)-oxime2×

Product 1

HCID 76750940HCID 76750940, compound

Procedure

The title compound was prepared from 2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime, compound 66, (30 mg, 0.087 mmol), 2-(chloro-ethyl)-morpholine hydrochloride (32 mg, 0.214 mmol) and sodium hydride (60% dispersion in oil) (18 mg, 0.470 mmol), following the same procedure used for 2-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(3-dimethylamino-propyl)-oxime (compound 88).

Sources & evidence

ORD record
ord-45688e9a3a06495bb9533b24aa58a7fb
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

Loading…