2-Amino-7-(2-bromo-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one → 2-Amino-7-[2-(1H-indol-7-yl)-phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one

HRID 2046511Notes

Reaction equation

HRID 2046511 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:8](=[O:13])[CH2:7][CH:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3Br)[CH2:5][C:4]=2[N:3]=1.NC1N=[C:30]([CH3:32])[C:29]2[C:28](=O)[CH2:27][CH:26](C3C=CC=CC=3C3C=CC=CC=3)[CH2:25][C:24]=2[N:23]=1>>[NH2:1][C:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:8](=[O:13])[CH2:7][CH:6]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:25]3[CH:26]=[CH:27][CH:28]=[C:29]4[C:24]=3[NH:23][CH:32]=[CH:30]4)[CH2:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 119791452-Amino-7-(2-bromo-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-oneHCID 582693442-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one

Product 1

HCID 582693832-Amino-7-[2-(1H-indol-7-yl)-phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one

Procedure

The title compound was prepared from 2-amino-7-(2-bromo-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/i stage 2/3), following the procedure describing the synthesis of 2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 5/a stage 1) using 7-boronic acid-1H-indole instead of phenyl-boronic acid.

Sources & evidence

ORD record
ord-ff77f81f0d1b498fa43fffeb4b149a70
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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