HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Acetate → 5-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-one | HCID 59473805 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-amine | HCID 68296745 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediates A-4 [A], 5-bromo-7-fluoro-indan-1-one was reacted with sodium cyanoborohydride and ammonium acetate in 2-propanol at reflux to yield the title compound as light yellow oil. MS: 228 (M−H−, 1Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592426B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-23c2e5839cc443d1b483fb0909d658cc |
| Source note | uspto-grants-2013_11 |