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HRID2046544

反应详情

EQUATION

反应方程式

HRID 2046544 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)[O-].[NH4+]
HCID517165

Ammonium acetate

C2H7NO2

结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：O=C1CCc2cc(Br)cc(F)c21
HCID59473805

5-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-one

C9H6BrFO

PRODUCTS

生成物

1
结构：NC1CCc2cc(Br)cc(F)c21
HCID68296745

5-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-amine

C9H9BrFN

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

In analogy to the procedure described for the preparation of intermediates A-4 [A], 5-bromo-7-fluoro-indan-1-one was reacted with sodium cyanoborohydride and ammonium acetate in 2-propanol at reflux to yield the title compound as light yellow oil. MS: 228 (M−H−, 1Br).

WORKUP

后处理

  1. customIn analogy to the procedure described for the preparation of intermediates
  2. temperatureat reflux