1,2-Oxazole-5-carboxylic acid → HCID 71229238, compound

HRID 2046605Notes

Reaction equation

HRID 2046605 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([F:30])[C:5]([C:24]2[N:25]=[N:26][N:27]([CH3:29])[N:28]=2)=[C:6]([C:8]2[CH:9]=[N:10][C:11]3[CH:12]([NH:17][C:18]([C:20]4([NH2:23])[CH2:22][CH2:21]4)=[O:19])[CH2:13][CH2:14][C:15]=3[CH:16]=2)[CH:7]=1.[O:31]1[C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=[N:32]1>>[Cl:1][C:2]1[CH:3]=[C:4]([F:30])[C:5]([C:24]2[N:25]=[N:26][N:27]([CH3:29])[N:28]=2)=[C:6]([C:8]2[CH:9]=[N:10][C:11]3[CH:12]([NH:17][C:18]([C:20]4([NH:23][C:36]([C:35]5[O:31][N:32]=[CH:33][CH:34]=5)=[O:37])[CH2:22][CH2:21]4)=[O:19])[CH2:13][CH2:14][C:15]=3[CH:16]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 20605991,2-Oxazole-5-carboxylic acidHCID 60141184HCID 60141184, compound

Product 1

HCID 71229238HCID 71229238, compound

Procedure

In analogy to the procedures described for the preparation of intermediate A-1 [B], 1-amino-cyclopropanecarboxylic acid{(rac)-3-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)-phenyl]-6,7-dihydro-5H-[1]pyrindin-7-yl}-amide (example 55) was coupled with isoxazole-5-carboxylic acid to yield the title compound as light yellow solid. MS: 523.1 (MH+, 1Cl).

Sources & evidence

ORD record
ord-dc8ac1245bb54198b1da9a1f334e08c9
Source dataset
uspto-grants-2013_11
Patent number
US08592426B2

Reaction notes

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