Acetyl chloride → 1-(2,3-Dichloro-4-fluoro-5-methylphenyl)ethanone

HRID 2046640Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[C:4]([F:9])[C:3]=1[Cl:10].[Cl-].[Al+3].[Cl-].[Cl-].[C:15](Cl)(=[O:17])[CH3:16]>>[Cl:1][C:2]1[C:3]([Cl:10])=[C:4]([F:9])[C:5]([CH3:8])=[CH:6][C:7]=1[C:15](=[O:17])[CH3:16]

Participants

Reactant 3

HCID 6367Acetyl chloride

HCID 6451240Aluminum(III) Chloride

HCID 593705023,4-Dichloro-2-fluorotoluene

Product 1

HCID 593704951-(2,3-Dichloro-4-fluoro-5-methylphenyl)ethanone

Procedure

Using 1,2-dichloro-3-fluoro-4-methylbenzene (12.0 g), anhydrous aluminum chloride (17.87 g) and acetyl chloride (5.26 g), the title compound was obtained as a pale-yellow oil (yield: 5.46 g) by an operation similar to that in Reference Example 9.

Sources & evidence

ORD record: ord-a7bd01da43c74d5c98fdd01a6e9a26db
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592452B2

Reaction notes

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