Lithium Carbonate → HCID 59370518, compound

HRID 2046667Notes

Reaction equation

HRID 2046667 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[OH:14][C:15]([C@H:18]1[CH2:22][CH2:21][NH:20][C@H:19]1[CH3:23])([CH3:17])[CH3:16].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:14][C:15]([C@H:18]1[CH2:22][CH2:21][N:20]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=2)[C@H:19]1[CH3:23])([CH3:17])[CH3:16]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370518HCID 59370518, compound

Procedure

Using 4-fluoro-2-(trifluoromethyl)benzonitrile (946 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (1.04 g) and lithium carbonate (784 mg), the title compound was obtained as a colorless solid (yield: 1.28 g) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-4ee848fe2cac469f8946011bfc2ae885
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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