Lithium Carbonate → HCID 16066093, compound

HRID 2046679Notes

Reaction equation

[Br:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[OH:11][C:12]([C@H:15]1[CH2:19][CH2:18][NH:17][C@H:16]1[CH3:20])([CH3:14])[CH3:13].C(=O)([O-])[O-].[Li+].[Li+]>>[Br:1][C:2]1[CH:9]=[C:8]([N:17]2[CH2:18][CH2:19][C@H:15]([C:12]([OH:11])([CH3:14])[CH3:13])[C@@H:16]2[CH3:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

Reactant 3

HCID 11125Lithium Carbonate

HCID 1189392-Bromo-4-fluorobenzonitrile

HCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 16066093HCID 16066093, compound

Procedure

Using 2-bromo-4-fluorobenzonitrile (497 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (659 mg) and lithium carbonate (259 mg), the title compound was obtained as a yellow solid (yield: 608 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record: ord-1685afa6c9a64b0382dda76e705c0468
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592452B2

Reaction notes

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