反应详情

Using 2-chloro-4-fluoroisophthalonitrile (503 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (629 mg) and lithium carbonate (259 mg), the title compound was obtained as a pale-yellow solid (yield: 540 mg) by an operation similar to that in Example 3.