HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2-chloro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]isophthalonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine | HCID 55299039 | — |
| Reactant | 2-Chloro-4-fluoroisophthalonitrile | HCID 59370516 | — |
| Product | 2-chloro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]isophthalonitrile | HCID 59370538 | — |
Reaction Steps
Using 2-chloro-4-fluoroisophthalonitrile (503 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (629 mg) and lithium carbonate (259 mg), the title compound was obtained as a pale-yellow solid (yield: 540 mg) by an operation similar to that in Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592452B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-37a3709d7fe04b09be655b64a3e3d6cf |
| Source note | uspto-grants-2013_11 |