HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2,5-difluoro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]-3-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 3-Methoxy-2,4,5-trifluorobenzonitrile | HCID 14096370 | — |
| Reactant | (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine | HCID 55299039 | — |
| Product | 2,5-difluoro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]-3-methoxybenzonitrile | HCID 59370542 | — |
Reaction Steps
Using 2,4,5-trifluoro-3-methoxybenzonitrile (347 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (409 mg) and lithium carbonate (328 mg), the title compound was obtained as a pale-yellow oil (yield: 175 mg) by an operation similar to that in Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592452B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d7787d95ead04a899be3c3098bbc91a7 |
| Source note | uspto-grants-2013_11 |