Lithium Carbonate → HCID 16066094, compound

HRID 2046686Notes

Reaction equation

HRID 2046686 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].CS(C)=O.[CH3:18][C@H:19]1[C@@H:23]([OH:24])[CH2:22][CH2:21][NH:20]1.C(=O)([O-])[O-].[Li+].[Li+]>>[OH:24][C@H:23]1[CH2:22][CH2:21][N:20]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=2[C:10]([F:13])([F:12])[F:11])[C@H:19]1[CH3:18]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 68603378HCID 68603378, compound

Product 1

HCID 16066094HCID 16066094, compound

Procedure

Using 4-fluoro-3-(trifluoromethyl)benzonitrile (398 mg), 0.9 mol/L (2S,3S)-2-methylpyrrolidin-3-ol dimethyl sulfoxide solution (2.35 mL) and lithium carbonate (156 mg), the title compound was obtained as yellow crystals (yield: 135 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-f4596f8980ec4ec8a6fe72feaa21252a
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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