HRID2046695

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7294

Methyl acrylate

C4H6O2

结构：CC(C)(C)OC(=O)N1CCC2(CC1)CC(=O)c1ccc(Br)cc1O2

HCID27281806

tert-Butyl 7-bromo-4-oxo-3,4-dihydro-1'H-spiro[1-benzopyran-2,4'-piperidine]-1'-carboxylate

C18H22BrNO4

结构：COC(=O)/C=C/c1ccc2c(c1)C(=O)CC1(CCNCC1)O2

HCID52952093

未命名化合物

PRODUCTS

生成物

结构：COC(=O)/C=C/c1ccc2c(c1)OC1(CCN(C(=O)OC(C)(C)C)CC1)CC2=O

HCID52952088

未命名化合物

PROCEDURE

实验过程

7-Bromo-4-oxo-spiro[chromane-2,4′-piperidine]-1′-carboxylic acid tert-butyl ester (9.1 g, 23 mmol) was treated with methyl acrylate according to the procedure for preparation of Intermediate 1, Step B, giving (E)-3-{1′-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4′-piperidine]-7-yl}-acrylic acid methyl ester (7.07 g) as a yellow solid.