反应详情

(E)-3-{1′-tert-Butoxycarbonyl-4-oxo-spiro[chromane-2,4′-piperidine]-7-yl}-acrylic acid methyl ester (2.45 g, 6.1 mmol) was deprotected with HCl according to the procedure for preparation of Intermediate 1, Step C, giving (E)-3-{4-oxo-spiro[chromane-2,4′-piperidine]-7-yl}-acrylic acid methyl ester (1.98 g) as a yellow solid (hydrochloride salt).