HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
tert-Butyl acrylate → (E)-3-{1-Benzyl-3',4'-dihydro-4'-oxo-spiro[piperidine-4,2'(1'H)-quinazoline]-6'-yl}-acrylic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | tert-Butyl acrylate | HCID 15458 | — |
| Edukt | 1-benzyl-6'-bromo-3',4'-dihydro-spiro[piperidine-4,2'(1H)-quinazoline]-4'-one | HCID 46077949 | — |
| Edukt | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Produkt | (E)-3-{1-Benzyl-3',4'-dihydro-4'-oxo-spiro[piperidine-4,2'(1'H)-quinazoline]-6'-yl}-acrylic acid tert-butyl ester | HCID 66932495 | — |
Reaktionsschritte
(E)-3-{1-Benzyl-3′,4′-dihydro-4′-oxo-spiro[piperidine-4,2′(1′H)-quinazoline]-6′-yl}-acrylic acid tert-butyl ester was synthesized starting from 1-benzyl-6′-bromo-3′,4′-dihydro-spiro[piperidine-4,2′(1′H)-quinazoline]-4′-one (600 mg, 1.55 mmol) and tert-butyl acrylate according to the procedure described for Intermediate 1, Step B, giving 486 mg of the product.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08592444B2 |
| Quelldatensatz | uspto-grants-2013_11 |
| ORD ID | ord-88a875c99cc043db81211b3ff9502b0d |
| Quellennotiz | uspto-grants-2013_11 |